Fxn CLIA Kit for Mouse(Mus musculus) | EIAab.comFxn CLIA Kit for Mouse(Mus musculus)

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Index > Protein center > Fxn(Gene name) > Mouse

Fxn (Gene name),

Frataxin, mitochondrial (Protein name ), FRDA_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fxn(Frda);

Protein name:

Frataxin, mitochondrial(Fxn);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer (probable predominant form). Oligomer. Interacts with LYRM4 AND HSPA9. Interacts with ACO1. Interacts with ISCU. Interacts with FECH; one iron-bound FXN monomer seems to interact with a FECH homodimer. Interacts with SDHA and SDHB. Interacts with ACO2; the interaction is dependent on citrate.

Function:

Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1.

Subcellular Location:

Cytoplasm Mitochondrion PubMed:17597094 describes localization exclusively in mitochondria.

Protein Attributes:

Sequence length:

207

Sequence:

50:

100:

150:

200:

207:

AYSGKGT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O35943

Pfam:

PF01491

SMR:

O35943

UniGene:

Mm.7319

KEGG:

mmu:14297

Uniprot:

O35943

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ELISA Kit for Mouse Fxn

Cat.:

E15247r

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96T

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ELISA Kit for Mouse Fxn

Cat.:

E15247h

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ELISA Kit for Mouse Fxn

Cat.:

E15247b

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96T

ELISA Kit for Mouse Fxn

Cat.:

E15247m

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96T

CLIA Kit for Mouse Fxn

Cat.:

U15247m

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96T

CLIA Kit for Mouse Fxn

Cat.:

U15247h

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96T

CLIA Kit for Mouse Fxn

Cat.:

U15247r

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96T

CLIA Kit for Mouse Fxn

Cat.:

U15247b

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96T

Polyclonal Antibody for Mouse Fxn

Cat.:

P15247Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Fxn

Cat.:

P15247Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Fxn

Cat.:

P15247Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse Fxn

Protein for Mouse Fxn

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin."
Koutnikova H. , Campuzano V. , Foury F. , Dolle P. , Cazzalini O. , Koenig M.
Nat. Genet.16:345-351(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
tissue: Embryo.
2.

"Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia."
Cavadini P. , O'Neill H.A. , Benada O. , Isaya G.
Hum. Mol. Genet.11:217-227(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
3.

"Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues."
Martelli A. , Wattenhofer-Donze M. , Schmucker S. , Bouvet S. , Reutenauer L. , Puccio H.
Hum. Mol. Genet.16:2651-2658(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
4.

"The in vivo mitochondrial two-step maturation of human frataxin."
Schmucker S. , Argentini M. , Carelle-Calmels N. , Martelli A. , Puccio H.
Hum. Mol. Genet.17:3521-3531(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
5.

"The first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxia."
Calmels N. , Schmucker S. , Wattenhofer-Donze M. , Martelli A. , Vaucamps N. , Reutenauer L. , Messaddeq N. , Bouton C. , Koenig M. , Puccio H.
PLoS ONE4:E6379-E6379(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
6.

"Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant."
Huang M.L. , Becker E.M. , Whitnall M. , Rahmanto Y.S. , Ponka P. , Richardson D.R.
Proc. Natl. Acad. Sci. U.S.A.106:16381-16386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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